Induction of hypertrophy in cultured proximal tubule cells by extracellular NH4Cl.
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چکیده
منابع مشابه
Induction of hypertrophy in cultured proximal tubule cells by extracellular NH4Cl.
Ammonia production increases in several models of renal hypertrophy in vivo. The present study was designed to determine whether ammonia can directly modulate the growth of renal cells in the absence of a change in extracellular acidity. In serum-free media NH4Cl (0-20 mM) caused JTC cells and a primary culture of rabbit proximal tubule cells to hypertrophy (increase in cell protein content) in...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1989
ISSN: 0021-9738
DOI: 10.1172/jci114361